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FUTURE DIRECTIONS Endothelial cell heterogeneity and spatial omics Emerging single-cell and spatial transcriptomic technologies have revealed substantial heterogeneity among ECs across different vascular beds, with distinct subpopulations associated with plaque rupture susceptibility, lipid transcytosis, and leukocyte adhesion [22,102]

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Schisandrin A directly interacts with adipoR1 to inhibit its ubiquitination and activate the AdipoR1/AMPK axis