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Without GPX4 activator, the downstream metabolites of the 5-LOX, 12-LOX, and 15-LOX pathways were markedly elevated after A23187 stimulation ( Figure 4 ), compared to the normal state ( Supplementary Figure S2 )

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However, clinical research in healthy adults shows that taking 1 gram of dong quai root daily for 3 weeks does not significantly inhibit platelet aggregation or cause bleeding