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Long-term oral exposure to PS-MPs causes significant deficits in learning and memory behaviors in mice (44), PS-MPs accumulate in the hippocampal region, affecting the expression of genes related to neural activity and synaptic proteins, inducing neuroinflammation, reducing the expression of immediate early genes, and altering synaptic protein profiles, ultimately leading to impaired learning and memory (44).In study on zebrafish (Symphysodon aequifasciatus) (45), micro- and nanoplastics were found to induce neurobehavioral toxicity through the brain-gut-microbiota axis