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OIS acts as a safeguard against the development of cancer by halting the growth of potentially malignant cells.14 In other words, oncogenic activation (eg, RAS, RAF, and MYC) can induce senescence as a protective mechanism against uncontrolled proliferation

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In ADPKD, low levels of the PC on the primary cilia and endoplasmic reticulum (ER) reduce the amount of intracellular calcium available through the PC2 calcium channel