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Apart from the deactivation of glial cells, DPP-4 inhibition with drugs such as tripeptide isoleucin-prolin-isoleucin, alogliptin, and the antidiabetic drug vildagliptin is reported to possess antihyperalgesic effects through opioid-dependent and opioid-independent mechanisms in inflammatory and neuropathic pain animal models (Xu et al., 2017

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The results were impressive—the Myers' Cocktail group maintained significant benefits in pain reduction and quality of life that lasted four weeks post-treatment