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However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007
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3 Beyond ATP generation, mitochondria play essential roles in metabolic signaling, intracellular calcium handling, and maintaining oxidative balance, a cell’s mechanism for managing reactive oxygen species (ROS) and cellular stress
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