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19–21 Double and triple variant MTHFR mutations of the 677CT and 1298AC loci in the MTHFR gene have been implicated in thrombophilic disease

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The sulfide in iron-sulfur clusters and in nitrogenase (enzymes responsible for the reduction of nitrogen which is a key step to the process of nitrogen fixation required for all forms of life) is extracted from cysteine and converted to alanine in the process