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Both methods have advantages and disadvantages, for example the high difficulty of detecting common genetic variants (for case-control association studies) or a better differentiation between the effects caused by environmental factors and those caused by genetic factors (in the case of family studies)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 274.Parker H.M., Cohn J.S., O’Connor H.T., Garg M.L., Caterson I.D., George J., Johnson N.A