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This directly activates the downstream Wnt/β-catenin, phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin (PI3 K/Akt/mTOR), mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), and AMP-activated protein kinase (AMPK) signaling pathways, promoting the expression of Cyclin D1 and cellular myelocytomatosis (c-Myc) in fibroid tissue [31–33]
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