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Moreover, the histidine imidazole Cu 2+ binding (anchoring) is followed when Cu 2+ is in a coordinated state, and this is achieved by the presence of two deprotonated backbone amides (Rivillas-Acevedo et al., 2013)

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Sterile water for injection is a single-use product: once the vial seal is broken, the absence of any preservative means that microbial contamination can occur with each subsequent access, making it unsuitable for the repeated needle access that is typical in peptide stock solution workflows