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Importantly, these alterations were attenuated by iron-induced death inhibitors (Fer-1 and DFO), further reinforcing the association between ferroptosis and the pathological mechanisms of LDH ( Figure 5 ) (174, 175)
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Inhibition of pyruvate dehydrogenase kinase 4 protects cardiomyocytes from lipopolysaccharide-induced mitochondrial damage by reducing lactate accumulation
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