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This regeneration of cytosolic NAD + is a critical rate-sustaining step, as it replenishes the electron acceptor pool required for the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) reaction, thereby maintaining continuous glycolytic flux and rapid ATP production [13]
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Nitric oxide is an important regulator and mediator of numerous processes in the nervous, immune and cardiovascular systems, and decreased methylation
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