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The treatment regimen was subsequently modified to a multi-agent combination: chidamide (20 mg twice weekly), decitabine (10 mg d1-5), mitoxantrone liposome (20 mg d2), bevacizumab (600mg day 1), bortezomib (2mg d1, 4, 8) and dexamethasone (20mg d1-4), repeated every 21days

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