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In the investigation of KRAS/LKB1/KEAP1 mutant lung adenocarcinoma cells, mild oxidative stress was observed to decrease NRF2 SUMOylation, which in turn enhanced the migration and invasion of these cells [132]

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Current interventions include treating the cause or source of the bleed and reducing its hemorrhagic load with either a surgical or minimally invasive decompression procedure [220]