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L-2-Hydroxyglutarate sensitizes ferroptosis through ATF3/CHAC1-mediated glutathione degradation in hepatocellular carcinoma | Cell Death & Disease
doi: 10.3389/fphar.2026.1742212 Received 08 November 2025 Revised 07 January 2026 Accepted 07 January 2026 Published 29 January 2026 Volume 17 - 2026 Edited by Patricia Rijo, Lusofona University, Portugal Reviewed by Ruolan Li, University of Electronic Science and Technology of China, China Lijuan Chen, Huazhong University of Science and Technology, China Updates Copyright © 2026 Zhao, Liu, Yu, Shen, Ding and Han
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In recent decades, the protective effects of mangiferin on human umbilical vein endothelial cells (HUVECs) have been extensively demonstrated (Fig