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Taken together, except for hif-1 mRNA, mRNA accumulation of the stress-responsive transcription factors analyzed was modulated by glucose treatment: it was increased for crh-1 and sbp-1 , and was decreased for cep-1 , skn-1 , and daf-16 , probably as part of a mechanism in which several signaling pathways participate to regain homeostasis in worms fed a HGD
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When it comes to CHI, the initial impact sets off a chain reaction of tissue damage, which in turn triggers additional injury or biochemical cascades that worsen the damage [1]
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