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Therefore, the intestine serves as a barrier tissue whereby a monolayer of intestinal epithelial cells establishes a multilayered physicochemical barrier ( The mucosal barrier also includes mucin, antimicrobial peptides, and dimeric (or more polymeric) IgA secreted by goblet cells, Paneth cells, and plasma cells, respectively ( Altered microbial composition, termed dysbiosis, has been implicated in mucosal barrier dysfunction and inflammatory responses, which predispose the host animals to systemic diseases (e.g., inflammatory bowel disease, celiac disease, food allergy, obesity, and autoimmune diseases) ( Table 1 )

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But they appear to have a higher risk of bone fractures and a recent study suggested an increase risk of haemorrhagic stroke