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The copper peptide's short plasma half-life means circulating levels decline rapidly after the final dose, and there is no evidence of stored copper accumulation at typical peptide dosing levels used in research settings 8
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In some embodiments, siRNA molecules encompassed by the invention comprise one or more (e.g., about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more) crosslinks, for example, a crosslink in which the sense strand is crosslinked to the antisense strand of the siRNA duplex
