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This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded α-synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging ( The interplay between mitochondrial function and GSH is especially critical in PD
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Patients with delayed improvement should be offered rehabilitative therapy, particularly for gait, urinary, or bowel dysfunction
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