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Smoking may be considered an established risk factor for sporadic ALS

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At present, clinical trials of ADCs continue to expand into novel target spaces, with ongoing programs directed against emerging tumor-associated antigens such as claudin-6 (CLDN6), delta-like ligand 3 (DLL3), mesothelin (MSLN), the zinc transporter LIV-1 (SLC39A6), and B7 homolog 4 (B7-H4), among others