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Patient-derived paediatric glioma (DIPG) cells were xenografted into the frontal cortex and subcortical white matter, and following a 5-week period of engraftment, cortical projection neuronal activity was optogenetically stimulated using our established protocol 1 (10-min session per day, 20 Hz blue-light stimulation with 30-s on/90-s off cycles) for 1 week