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For example, NAM can inhibit the activity of human sirtuin 1 (SIRT1) and PARPs in vitro 55,56
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Over a period of 6 months, patients lost an average of 12.8 kg, 11.3 kg, and 6.7 kg on the 1 mg, 0.5 mg, and 0.25 mg doses, respectively, as compared to a 2.2 kg weight loss in the placebo group [76]
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