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Deletion of GPR37 enhances A 2 AR cell surface expression and function, leading to increased cyclic adenosine monophosphate (cAMP) accumulation in response to A 2 AR agonists

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By contrast, GLP‐1 has limited direct receptor expression in adipocytes, and its effects are largely indirect via autonomic and metabolic pathways, including increased sympathetic tone driving lipolysis of stored triglycerides [13]