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However, certain GPCRs, such as GnIHR (gonadotropin-inhibitory hormone receptor), lack both the H8 and C-tail 40

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The mechanism entails the release of SP from nerve endings (enteric neurons and/or extrinsic afferent nerves) that activate eosinophils via neurokinin receptors (NKR1 and NKR2) to produce CRH