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Complementary in vitro investigations revealed that cerivastatin and fluvastatin upregulated mRNA expression of GTP cyclohydrolase (GTPCH), the rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, and increased endothelial nitric oxide synthase (eNOS) abundance in human umbilical vein endothelial cells (HUVECs) [287]
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