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As a result, an accumulation of Lipid-OOH occurs: since GSH is the reducing co-substrate of GPX4, able to regulate the redox state of the cell-forming Lipid-OH (Figure 2A), GSH depletion can negatively regulate GPX4, triggering ferroptosis [19]

Reducing ulcerative colitis damage

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As a cautionary note, however, current conclusions cannot extend beyond a dose of 15 g of glycine per day, which is the highest dose well tolerated in adult humans [125]