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Frequency and Intensity of Side-effect Rating (FISER)/Global Rating of Side-effect Burden (GRSEB)/ Patient Report of Incidence of Side-Effects (PRISE) The FISER/GRSEB/PRISE include global measures, each using a 7-point Likert-type scale rated 0–6, one rating anchored for frequency, another rating the intensity of side-effects encountered in the prior week that the caregiver believes were due to the treatment, and the third asking caregivers to estimate the overall burden or degree of interference in day-to-day activities and function due to the side-effects attributable specifically to the treatment [12]

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In the systemic physiological environment, the glycocalyx, consisting of the sialo-glycoconjugates and heparan sulfate proteoglycans expressed on the luminal surface of BCECs, contributes to an overall negative charge of BBB 14