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But Sir, I say, the last forementioned Addresse, touching Prince Cromwell and his associates to the quick, hee most unjustly compelled your mock House, in effect, to vote &illegible

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As genotypes with multiple mutations appear at later timepoints than single mutants, the analysis of intermediate activity suggests that redesign expanded functional sequences to include those closer to the starting point, allowing the redesigned protease to adapt to the 413 substrate in less time and with fewer mutations than the WT protease