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Exploring the potential of anticancer peptides as... : Research in Pharmaceutical Sciences
Although direct evidence of diminished inhibitory phosphorylation at Ser9 in obese WAT has been limited, our findings demonstrate that adipocyte-specific deletion of Ssu72 significantly increases GSK3β phosphorylation at Ser9 under HFD conditions, suggesting that Ssu72 is integral to driving maladaptive changes by maintaining GSK3β in its active, dephosphorylated state, resembling the regulatory mechanism reported for Dyrk1A [68]
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The acetylated polyamines can be exported from cells via heteromeric transporters containing the SLC3A2 encoded heavy chain subunit
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