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This reaction usually manifests as temporary redness, swelling, or tenderness and typically resolves within a few days without intervention

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We downloaded raw IDAT files produced by the Illumina iScan system from the GDC data portal ( We calculated DNA methylation levels ( β values) from the IDAT files using the openSesame pipeline with the default arguments implemented in the R package SeSAMe (v.1.18.4) 125