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SC depth: 4–8 mm (adipose tissue layer) IM depth: 25–38 mm (skeletal muscle belly) SC angle: 45–90 degrees depending on tissue thickness IM angle: 90 degrees perpendicular to skin surface SC capillary density: moderate — slower absorption IM capillary density: high — faster absorption Absorption Speed and Pharmacokinetics The pharmacokinetic profile of a peptide changes significantly depending on the injection route

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Parent JM, Elliott RC, Pleasure SJ, Barbaro NM, Lowenstein DH