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The STEP 1 trial demonstrated 14.9% body weight reduction, and the SELECT trial showed 20% MACE reduction

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ROS induces the activation of mitogen activated kinase (MAPK), downregulates the phosphorylation level of extracellular regulatory protein kinase (p-ERK), upregulates activated nuclear transcription factor (NF-KB), activates autophagy pathway, and leads to apoptosis of retinal photoreceptor cells