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Low levels of adiponectin may enhance type 2 airway inflammation by diminishing AMPK-mediated feedback inhibition of IL-33/NF-κB signaling in immune cells such as ILC2s, thereby linking metabolic dysregulation to asthma pathogenesis

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NADPH oxidases (NOX) are considered the principal ROS producers in the cardiovascular system, contributing to the formation of superoxide anions by transferring electrons from NADPH to molecular oxygen