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Consequently, this disruption promotes cellular lipid peroxidation and iron-dependent cell death, facilitating viral replication ( Figure 5 4.1.5 Herpesviruses Herpesviruses, including herpes simplex virus types 1 and 2 (HSV-1/2), varicella zoster virus (VZV), EBV, and human herpesviruses 6, 7, and 8 (HHV-6/7/8), are DNA viruses within the Herpesviridae family

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In clinical studies, nasal delivery devices can include: nose droppers, sprays, needleless syringes, breath-powered bi-directional nasal devices, pressurized meter dose inhalers, and pressurized olfactory delivery [8,9,18]