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The efficacy of this approach has been demonstrated in studies showing improvements in social behaviors achieved by inhibiting excitatory activity through the use of NMDA receptor antagonists, e.g., subanesthetic doses of Xenon [50] and memantine in VPA-exposed rats [51] and NitroSynapsin in Mef2c +/− mice [52], as well as through modulation of AMPA receptors by risperidone in a VPA model [53]
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