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Abbreviations AC Autoimmune cholestatic liver diseases ADH Alcohol dehydrogenase AIH Autoimmune hepatitis ALD Alcoholic liver disease ALP Alkaline phosphatase ALT Alanine transaminase ALDH Aldehyde dehydrogenases ARE Antioxidant response element AST Aspartate aminotransferase BHA Butylated hydroxyanisole bw Body weight CAT Catalase CCl 4 Carbon tetrachloride ER Endoplasmic reticulum GSH-Px Glutathione peroxidase GSH Glutathione GRD Glutathione reductase GST Glutathione S-transferase HDL High density lipoprotein HCV Hepatitis C virus IL-6 Interleukin 6 INH Anti-tuberculosis agent isoniazid iNOS Inducible nitric oxide synthase (iNOS) INrf2 Inhibitor of Nrf2 IKKβ IκB kinase-β IRS Insulin receptor substrate JNK c-Jun N-terminal kinases Keap1 kelch-like ECH-associated protein-1 LDH lactate dehydrogenase LDL Low density lipoprotein MDA Malondialdehyde MEOS Microsomal ethanol oxidizing system NADPH Nicotinamide adenine dinucleotide phosphate-oxidase NAFLD Non-alcoholic fatty liver disease NAFLD NO Nitric Oxide NQO1 NAD(P)H Dehydrogenase, Quinone 1 Nrf1 Nuclear respiratory factor 1 Nrf2 Erythroid 2-related factor 2 PKC protein kinase C PPARα Peroxisome proliferator activated receptor α RNS Reactive nitrogen species ROS Reactive oxygen species (ROS) SOD Superoxide dismutases TAA Thioacetamide TB Total bilirubin TBARS Thiobarbituric acid-reactive substances TNF Tumor necrosis factor Author Contributions Sha Li wrote the manuscript