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The main reported collateral effects are statin-associated muscle symptoms (SAMSs) such as myalgia, myopathy, myositis, and even worse rhabdomyolysis, as well as new onset type 2 diabetes mellitus, neuropsychiatric effects such as depression, sleep problems etc., hepatotoxicity, microbiome-mediated effects, and finally renal toxicity, to name only some [137]

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Most of them happen to be unstable and susceptible to degradation or oxidation, while others prove to be of poor water solubility which therefore implies poor bioavailability to act on the target site

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