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This binding transcriptionally upregulates the expression of a series of key genes, including GCLC, GCLM (the light chain of GCLC), and xCT (system xc⁻, responsible for cysteine uptake), thereby increasing GSH synthesis and cysteine uptake, thereby strengthening the cell's antioxidant defenses

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Still, factors like stress, pollution, alcohol, and age can diminish glutathione levels, which ultimately help protect our cells from these factors