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While a study found declined levels of NAD + and NAMPT levels and mitochondrial function in human sarcopenic muscle 249 , another study demonstrated no notable difference in NAD + or NAMPT levels in sarcopenic muscle of human patients 262

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In agreement with the effects of DMF on intracellular calcium regulation, we also observed that DMF decreased calcium-dependent cell secretion from G93A iPSAs, but not control cells (Fig 7H)