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58 Cytokines secreted by the IL-1/TLR signaling pathway, in which IRAK4 is involved, such as IL-36, IL-17, TNF-α, IFN-γ, and IL-1β, assume important roles in the pathogenesis of HS

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It should be noted that one study performed single-unit SSNA recordings from sudomotor neurons during heat stress, demonstrating that sudomotor neurons are characterized by a low firing probability and that they display some cardiac and respiratory rhythmicity (156, 157)