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Additionally, melatonin inhibits various pro-inflammatory events, such as amyloid toxicity, NO release, cyclooxygenase-2 (Cox-2) and NLRP3 inflammasome activation, toll-like receptor 4 (TLR4) and mammalian target of rapamycin (mTOR) signaling, as well as the release of senescence-associated secretory phenotype cytokines

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