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[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Mullen AR, et al

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When stratified by administration route, the average percentage reductions were: Intramuscular (IM): −48.3% Sublingual: −30.7% Oral: −30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects