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The inhibition capacity of any compound against the target is a function of the type of nonbonding interactions that occur between such complexes (Latona et al., 2022b)

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In a study with 10 advanced melanoma patients resistant to anti-PD-1 therapy, a combination of ziv-aflibercept and pembrolizumab led to a partial response in 2 patients with mucosal melanoma and stable disease in 2 patients with ocular melanoma 209