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Duration: Four to six weeks, beginning two to three weeks after fracture (during the transition from soft to hard callus formation)

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Treatment of rat brain sagittal slice cultures with LPC induces robust demyelination To assess the effect of a different demyelinating compound on brain slice cultures, slices were treated with LPC for 17 h and the expression of MBP and MOG was assessed over 6 weeks of culture (5 weeks post-treatment)