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This similarity of action by two activators which act on different portions of the channel subunit, and the congruence of the dose-response profiles for in vitro respiratory rhythm depression and activation of recombinant KCNQ channels, provides strong pharmacological evidence for involvement of KCNQ potassium channels in the modulation or generation of preBötC inspiratory rhythms
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The algorithm uses recursive parameter identification to adapt to changes in insulin requirements, while Kalman filters update physiologic model states at each time step for personalized predictions
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